Scientific Support & Reference Citations

 

Inhoudsopgave

Sleep Pack

Ingrediënten Sleep Pack

Choline

Valeriaan

Magnesium

Californian Poppy

Passie bloem

Tranq 3 (Gaba)

Melatonine

META+

Ingrediënten Meta+

S. Indicus

Garcina Mangostana

Bioperine

Sugar Hush

Ingrediënten Sugar Hush 6

Ceylon Kaneel

Kudzu wortel extract

Gymnema Sylvestre

Bioperine

After Party Pack

Ingrediënten After Party Pack

Zinc Methionine

Magnesium

Alpha Liponzuur

Asparaginezuur

Maria Distel

Sleep Pack

Ingrediënten Sleep Pack

Choline

Valeriaan

Magnesium Citraat

Californian poppy

Passiebloem

Tranq 3 (GABA)

Melatonine

 

Choline

Laad bronnen

Choline and betaine in health and disease . J Inherit Metab Dis. (2011)

Yan J et al. MTHFR C677T genotype influences the isotopic enrichment of one-carbon metabolites in folate-compromised men consuming d9-choline . Am J Clin Nutr. (2011)

Cohen BM, et al Decreased brain choline uptake in older adults. An in vivo proton magnetic resonance spectroscopy study . JAMA. (1995) Biochem Pharmacol. (1998)

Mayr M Recent highlights of metabolomics in cardiovascular research . Circ Cardiovasc Genet. (2011)

Warber JP, et al The effects of choline supplementation on physical performance . Int J Sport Nutr Exerc Metab. (2000)

Spector SA, et al Effect of choline supplementation on fatigue in trained cyclists . Med Sci Sports Exerc. (1995)

Valeriaan

Laad bronnen

Maroo N, Hazra A, Das T Efficacy and safety of a polyherbal sedative-hypnotic formulation NSF-3 in primary insomnia in comparison to zolpidem: a randomized controlled trial . Indian J Pharmacol. (2013)

Taavoni S, Nazem Ekbatani N, Haghani H Valerian/lemon balm use for sleep disorders during menopause . Complement Ther Clin Pract. (2013)

Houghton PJ The scientific basis for the reputed activity of Valerian . J Pharm Pharmacol. (1999)

Fernández S, et al Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis . Pharmacol Biochem Behav. (2004)

Yuan CS, et al The gamma-aminobutyric acidergic effects of valerian and valerenic acid on rat brainstem neuronal activity . Anesth Analg. (2004)

Andreatini R, et al Effect of valepotriates (valerian extract) in generalized anxiety disorder: a randomized placebo-controlled pilot study . Phytother Res. (2002)

Francis AJ, Dempster RJ Effect of valerian, Valeriana edulis, on sleep difficulties in children with intellectual deficits: randomised trial . Phytomedicine. (2002)

Bent S, et al Valerian for sleep: a systematic review and meta-analysis . Am J Med. (2006)

Wheatley D Kava and valerian in the treatment of stress-induced insomnia . Phytother Res. (2001)

Taavoni S, et al Effect of valerian on sleep quality in postmenopausal women: a randomized placebo-controlled clinical trial . Menopause. (2011)

Cuellar NG, Ratcliffe SJ Does valerian improve sleepiness and symptom severity in people with restless legs syndrome . Altern Ther Health Med. (2009)

Magnesium

Laad bronnen

The effect of melatonin, magnesium, and zinc on primary insomnia in long-term care facility residents in Italy: a double-blind, placebo-controlled clinical trial

Fox C, Ramsoomair D, Carter C Magnesium: its proven and potential clinical significance . South Med J. (2001)

Langley WF, Mann D Central nervous system magnesium deficiency . Arch Intern Med. (1991)

Takase B, et al Effect of chronic stress and sleep deprivation on both flow-mediated dilation in the brachial artery and the intracellular magnesium level in humans .Clin Cardiol. (2004)

Spasov AA, et al Depression-like and anxiety-related behaviour of rats fed with magnesium-deficient diet . Zh Vyssh Nerv Deiat Im I P Pavlova. (2008)

Eby GA 3rd, Eby KL Magnesium for treatment-resistant depression: a review and hypothesis . Med Hypotheses. (2010)

Barragán-Rodríguez L, Rodríguez-Morán M, Guerrero-Romero F Efficacy and safety of oral magnesium supplementation in the treatment of depression in the elderly with type 2 diabetes: a randomized, equivalent trial . Magnes Res. (2008)

Rodríguez-Morán M, Guerrero-Romero F Oral magnesium supplementation improves insulin sensitivity and metabolic control in type 2 diabetic subjects: a randomized double-blind controlled trial . Diabetes Care. (2003)

The effect of melatonin, magnesium, and zinc on primary insomnia in long-term care facility residents in Italy: a double-blind, placebo-controlled clinical trial

Fox C, Ramsoomair D, Carter C Magnesium: its proven and potential clinical significance . South Med J. (2001)

Langley WF, Mann D Central nervous system magnesium deficiency . Arch Intern Med. (1991)

Takase B, et al Effect of chronic stress and sleep deprivation on both flow-mediated dilation in the brachial artery and the intracellular magnesium level in humans .Clin Cardiol. (2004)

Spasov AA, et al Depression-like and anxiety-related behaviour of rats fed with magnesium-deficient diet . Zh Vyssh Nerv Deiat Im I P Pavlova. (2008)

Eby GA 3rd, Eby KL Magnesium for treatment-resistant depression: a review and hypothesis . Med Hypotheses. (2010)

Barragán-Rodríguez L, Rodríguez-Morán M, Guerrero-Romero F Efficacy and safety of oral magnesium supplementation in the treatment of depression in the elderly with type 2 diabetes: a randomized, equivalent trial . Magnes Res. (2008)

Rodríguez-Morán M, Guerrero-Romero F Oral magnesium supplementation improves insulin sensitivity and metabolic control in type 2 diabetic subjects: a randomized double-blind controlled trial . Diabetes Care. (2003)

Garland HO New experimental data on the relationship between diabetes mellitus and magnesium . Magnes Res. (1992)

Cinar V, et al The effect of magnesium supplementation on glucose and insulin levels of tae-kwan-do sportsmen and sedentary subjects . Pak J Pharm Sci. (2008)

Celik N, Andiran N, Yilmaz AE The relationship between serum magnesium levels with childhood obesity and insulin resistance: a review of the literature . J Pediatr Endocrinol Metab. (2011)

Aagaard NK, et al Muscle strength, Na,K-pumps, magnesium and potassium in patients with alcoholic liver cirrhosis -- relation to spironolactone . J Intern Med. (2002)

Cinar V, et al Effects of magnesium supplementation on testosterone levels of athletes and sedentary subjects at rest and after exhaustion . Biol Trace Elem Res. (2011)

Californian Poppy

Laad bronnen

Double-blind, randomised, placebo-controlled study to evaluate the efficacy and safety of a fixed combination containing two plant extracts (Crataegus oxyacantha and Eschscholtzia californica) and magnesium in mild-to-moderate anxiety disorders

Kleber E, et al Modulation of key reactions of the catecholamine metabolism by extracts from Eschscholtzia californica and Corydalis cava .Arzneimittelforschung. (1995)

Rolland A, et al Behavioural effects of the American traditional plant Eschscholzia californica: sedative and anxiolytic properties . Planta Med. (1991)

Rolland A, et al Neurophysiological effects of an extract of Eschscholzia californica Cham. (Papaveraceae) . Phytother Res. (2001)

Cahlíko1vá L, et al Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Eschscholzia californica (Papaveraceae) . Nat Prod Commun. (2010)

Passie bloem

Laad bronnen

Maroo N, Hazra A, Das T Efficacy and safety of a polyherbal sedative-hypnotic formulation NSF-3 in primary insomnia in comparison to zolpidem: a randomized controlled trial . Indian J Pharmacol. (2013)

Taavoni S, Nazem Ekbatani N, Haghani H Valerian/lemon balm use for sleep disorders during menopause . Complement Ther Clin Pract. (2013)

Houghton PJ The scientific basis for the reputed activity of Valerian . J Pharm Pharmacol. (1999)

Fernández S, et al Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis . Pharmacol Biochem Behav. (2004)

Barton DL, et al The use of Valeriana officinalis (Valerian) in improving sleep in patients who are undergoing treatment for cancer: a phase III randomized, placebo-controlled, double-blind study (NCCTG Trial, N01C5) . J Support Oncol. (2011)

Müller CE, et al Interactions of valerian extracts and a fixed valerian-hop extract combination with adenosine receptors . Life Sci. (2002)

Tranq 3 (Gaba)

Laad bronnen

Petroff OA GABA and glutamate in the human brain . Neuroscientist. (2002)

Efflux of a suppressive neurotransmitter, GABA, across the blood–brain barrier

Cavagnini F, et al Effect of acute and repeated administration of gamma aminobutyric acid (GABA) on growth hormone and prolactin secretion in man . Acta Endocrinol (Copenh). (1980) .

Powers ME, et al Growth hormone isoform responses to GABA ingestion at rest and after exercise . Med Sci Sports Exerc. (2008)

Melatonine

Laad bronnen

Bubenik GA, Konturek SJ Melatonin and aging: prospects for human treatment . J Physiol Pharmacol. (2011)

Hardeland R Melatonin, hormone of darkness and more: occurrence, control mechanisms, actions and bioactive metabolites . Cell Mol Life Sci. (2008)

Arendt J, et al Some effects of melatonin and the control of its secretion in humans . Ciba Found Symp. (1985)

Waldhauser F, Kovács J, Reiter E Age-related changes in melatonin levels in humans and its potential consequences for sleep disorders . Exp Gerontol. (1998)

Pandi-Perumal SR, et al Melatonin and sleep in aging population . Exp Gerontol. (2005)

Ferini-Strambi L, et al Effect of melatonin on sleep microstructure: preliminary results in healthy subjects . Sleep. (1993)

James SP, et al The effect of melatonin on normal sleep . Neuropsychopharmacology. (1987)

Cramer H, et al On the effects of melatonin on sleep and behavior in man . Adv Biochem Psychopharmacol. (1974)

Waldhauser F, Saletu B, Trinchard-Lugan I Sleep laboratory investigations on hypnotic properties of melatonin . Psychopharmacology (Berl). (1990)

Zhdanova IV, et al Sleep-inducing effects of low doses of melatonin ingested in the evening . Clin Pharmacol Ther. (1995)

Zhdanova IV, et al Effects of low oral doses of melatonin, given 2-4 hours before habitual bedtime, on sleep in normal young humans . Sleep. (1996)

Pinto LR Jr, Seabra Mde L, Tufik S Different criteria of sleep latency and the effect of melatonin on sleep consolidation . Sleep. (2004)

Wade AG, et al Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety . BMC Med. (2010)

Efficacy of Melatonin Treatment in Jet Lag, Shift Work, and Blindness

Herxheimer A, Petrie KJ Melatonin for the prevention and treatment of jet lag . Cochrane Database Syst Rev. (2002)

Wade AG, et al Efficacy of prolonged release melatonin in insomnia patients aged 55-80 years: quality of sleep and next-day alertness outcomes . Curr Med Res Opin. (2007)


Sugar Hush

Ingrediënten Sugar Hush

 

Ceylon Kaneel

Kudzu wortel extract

Gymnema Sylvestre

Bioperine

 

Ceylon Kaneel

Laad bronnen

Abraham K, et al Toxicology and risk assessment of coumarin: focus on human data . Mol Nutr Food Res. (2010)

A Hydroxychalcone Derived from Cinnamon Functions as a Mimetic for Insulin in 3T3-L1 Adipocytes

Mohamed Sham Shihabudeen H, Hansi Priscilla D, Thirumurugan K Cinnamon extract inhibits α-glucosidase activity and dampens postprandial glucose excursion in diabetic rats . Nutr Metab (Lond). (2011)

Adisakwattana S, et al Inhibitory activity of cinnamon bark species and their combination effect with acarbose against intestinal α-glucosidase and pancreatic α-amylase . Plant Foods Hum Nutr. (2011)

Isolation and Characterization of Chalcone Polymers from Cinnamon with Insulin-Like Biological Activity

Imparl-Radosevich J, et al Regulation of PTP-1 and insulin receptor kinase by fractions from cinnamon: implications for cinnamon regulation of insulin signalling .Horm Res. (1998)

Broadhurst CL, Polansky MM, Anderson RA Insulin-like biological activity of culinary and medicinal plant aqueous extracts in vitro . J Agric Food Chem. (2000)

Kirkham S, et al The potential of cinnamon to reduce blood glucose levels in patients with type 2 diabetes and insulin resistance . Diabetes Obes Metab. (2009)

Pham AQ, Kourlas H, Pham DQ Cinnamon supplementation in patients with type 2 diabetes mellitus . Pharmacotherapy. (2007)

Mang B, et al Effects of a cinnamon extract on plasma glucose, HbA, and serum lipids in diabetes mellitus type 2 . Eur J Clin Invest. (2006)

Khan A, et al Cinnamon improves glucose and lipids of people with type 2 diabetes . Diabetes Care. (2003)

Anderson RA Chromium and polyphenols from cinnamon improve insulin sensitivity . Proc Nutr Soc. (2008)

Qin B, Panickar KS, Anderson RA Cinnamon: potential role in the prevention of insulin resistance, metabolic syndrome, and type 2 diabetes . J Diabetes Sci Technol. (2010)

Solvent-assisted supercritical fluid extraction for the isolation of semivolatile flavor compounds from the cinnamons of commerce and their separation by series-coupled column gas chromatography

Woehrlin F, et al Quantification of flavoring constituents in cinnamon: high variation of coumarin in cassia bark from the German retail market and in authentic samples from indonesia . J Agric Food Chem. (2010)

Abraham K, et al Relative bioavailability of coumarin from cinnamon and cinnamon-containing foods compared to isolated coumarin: a four-way crossover study in human volunteers . Mol Nutr Food Res. (2011)

 

Kudzu wortel extract

Laad bronnen

Li YB, et al Protective, antioxidative and antiapoptotic effects of 2-methoxy-6-acetyl-7-methyljuglone from Polygonum cuspidatum in PC12 cells . Planta Med. (2011)

Jensen JS, Wertz CF, O'Neill VA Preformulation stability of trans-resveratrol and trans-resveratrol glucoside (Piceid) . J Agric Food Chem. (2010)

Cai Y, et al Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer . Life Sci. (2004)

Han JH, et al Analgesic and anti-inflammatory effects of ethyl acetate fraction of Polygonum cuspidatum in experimental animals . Immunopharmacol Immunotoxicol. (2012)

Gymnema Sylvestre

Laad bronnen

Pothuraju R, et al, Anti-obesity effect of milk fermented by Lactobacillus plantarum NCDC 625 alone and in combination with herbs on high fat diet fed C57BL/6J mice. Benef Microbes. (2016)

Bera R, et al In Vitro Metabolic Stability and Permeability of Gymnemagenin and Its In Vivo Pharmacokinetic Correlation in Rats - A Pilot Study. Planta Med. (2016)

Kamble B et al, Effects of Gymnema sylvestre extract on the pharmacokinetics and pharmacodynamics of glimepiride in streptozotocin induced diabetic rats. Chem Biol Interact. (2016)

Rathore PK et al, In-silico analysis of gymnemagenin from Gymnema sylvestre (Retz.) R.Br. with targets related to diabetes. J Theor Biol. (2016)

Li Y et al, EFFECT OF-GYMNEMA SYLVESTRE, CITRULLUS COLOCYNTHIS AND ARTEMISIA ABSINTHIUM ON BLOOD GLUCOSE AND LIPID PROFILE IN DIABETIC HUMAN. Acta Pol Pharm. (2015).

Singh VK et al, Gymnemic Acid Stimulates In Vitro Splenic Lymphocyte Proliferation. Phytother Res. (2016)

Singh VK et al, Immunomodulatory Effect of Gymnema sylvestre (R.Br.) Leaf Extract: An In Vitro Study in Rat Model. PLoS One. (2015)

Pothuraju R, et al¸ Influence of milk fermented with Lactobacillus rhamnosus NCDC 17 alone and in combination with herbal ingredients on diet induced adiposity and related gene expression in C57BL/6J mice. Food Funct. (2015)

Goyal M. et al, Traditional plants used for the treatment of diabetes mellitus in Sursagar constituency, Jodhpur, Rajasthan - An ethnomedicinal survey. J Ethnopharmacol. (2015)

Fatani AJ, et al, Neuroprotective effects of <i>Gymnema sylvestre</i> on streptozotocin-induced diabetic neuropathy in rats. Exp Ther Med. (2015).

Perera HK, et al, Analysis of glycation induced protein cross-linking inhibitory effects of some antidiabetic plants and spices. BMC Complement Altern Med. (2015)

Pon Nivedha R, et al, Effects of dihydroxy gymnemic triacetate (DGT) on expression of apoptosis associated proteins in human prostate cancer cell lines (PC3). J Recept Signal Transduct Res. (2015)

Borse SP, et al, Effects of Ayurvedic Rasayana botanicals on CYP3A4 isoenzyme system. J Integr Med. (2015)

Grise DE, et al, Improved clinical outcomes of patients with type 2 diabetes mellitus utilizing integrative medicine: a case report. Glob Adv Health Med. (2015)

Di Fabio G, et al, Gymnema sylvestre R. Br., an Indian medicinal herb: traditional uses, chemical composition, and biological activity. Curr Pharm Biotechnol. (2015)

Xu R, et al, New pregnane glycosides from Gymnema sylvestre. Molecules. (2015)

Renga B, et al, Molecular decodification of gymnemic acids from Gymnema sylvestre. Discovery of a new class of liver X receptor antagonists. Steroids. (2015).

Arunachalam KD, et al, Potential anticancer properties of bioactive compounds of Gymnema sylvestre and its biofunctionalized silver nanoparticles. Int J Nanomedicine. (2014)

Ahamad J, et al¸ Simultaneous Quantification of Gymnemic Acid as Gymnemagenin and Charantin as β-Sitosterol Using Validated HPTLC Densitometric Method. Nat Prod Commun. (2014)

Bioperine

Laad bronnen

Shoba G, et al Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers . Planta Med. (1998)

Srinivasan K Black pepper and its pungent principle-piperine: a review of diverse physiological effects . Crit Rev Food Sci Nutr. (2007)


META+

Ingrediënten Meta+

 

S. Indicus

Garcina Mangostana

Bioperine

 

S. Indicus

Laad bronnen

Stern, J. S., et al. "Efficacy and tolerability of a novel herbal formulation for weight management." Obesity 21.5 (2013): 921-927.

Stern, J. S., et al. "Efficacy and tolerability of a novel herbal formulation for weight management." J Med Food. Jun 2013; 16(6): 529–537.

Nahata A, et al Sphaeranthus indicus Induces Apoptosis Through Mitochondrial-Dependent Pathway in HL-60 Cells and Exerts Cytotoxic Potential on Several Human Cancer Cell Lines . Integr Cancer Ther. (2012)

Kovendan K, et al Larvicidal efficacy of Sphaeranthus indicus, Cleistanthus collinus and Murraya koenigii leaf extracts against filarial vector, Culex quinquefasciatus Say (Diptera: Culicidae) . Parasitol Res. (2012)

An immunostimulant sesquiterpene glycoside from Sphaeranthus indicus

A chemical investigation of sphaeranthus indicus linn

Isolation, Purification and Structural determination of Biological and Pharmacologicaly Active Alkaloids

Pujar PP, et al Eudesmanoids from Sphaeranthus indicus . Fitoterapia. (2000)

Patel MB, Amin D Sphaeranthus indicus flower derived constituents exhibits synergistic effect against acetylcholinesterase and possess potential antiamnestic activity . J Complement Integr Med. (2012)

New Eudesmanolides from Sphaeranthus indicus

An Antimicrobial Principle from Sphaeranthus indicus L. (Family Compositae)

Mishra BB, et al A novel flavonoid C-glycoside from Sphaeranthus indicus L. (family Compositae) . Molecules. (2007)

A novel isoflavone glycoside from the leaves of Sphaeranthus indicus

Doss A Preliminary phytochemical screening of some Indian Medicinal Plants . Anc Sci Life. (2009)

Shirwaikar A, Prabhu KS, Punitha IS In vitro antioxidant studies of Sphaeranthus indicus (Linn) . Indian J Exp Biol. (2006)

Fonseca LC, et al 7-hydroxyfrullanolide, a sesquiterpene lactone, inhibits pro-inflammatory cytokine production from immune cells and is orally efficacious in animal models of inflammation . Eur J Pharmacol. (2010)

Galani VJ, Patel BG Effect of hydroalcoholic extract of Sphaeranthus indicus against experimentally induced anxiety, depression and convulsions in rodents . Int J Ayurveda Res. (2010)

Ali A, et al Anti-inflammatory and analgesic activities of ethanolic extract of Sphaeranthus indicus Linn . Pak J Pharm Sci. (2011)

Ramachandran S, et al Investigation of Antidiabetic, Antihyperlipidemic, and In Vivo Antioxidant Properties of Sphaeranthus indicus Linn. in Type 1 Diabetic Rats: An Identification of Possible Biomarkers . Evid Based Complement Alternat Med. (2011)

Prabhu KS, Lobo R, Shirwaikar A Antidiabetic properties of the alcoholic extract of Sphaeranthus indicus in streptozotocin-nicotinamide diabetic rats . J Pharm Pharmacol. (2008)

Ghaisas M, et al Preventive effect of Sphaeranthus indicus during progression of glucocorticoid-induced insulin resistance in mice . Pharm Biol. (2010)

Nahata A, Dixit VK Sphaeranthus indicus attenuates testosterone induced prostatic hypertrophy in albino rats . Phytother Res. (2011)

Mathew JE, et al Mast cell stabilizing effects of Sphaeranthus indicus . J Ethnopharmacol. (2009)

Bafna AR, Mishra SH Immunomodulatory activity of petroleum ether extract of flower heads of Sphaeranthus indicus Linn . J Herb Pharmacother. (2007)

Bafna AR, Mishra SH Protective effect of bioactive fraction of Sphaeranthus indicus Linn. against cyclophosphamide induced suppression of humoral immunity in mice . J Ethnopharmacol. (2006)

Mathew JE, et al Effect of ethanol extract of Sphaeranthus indicus on cisplatin-induced nephrotoxicity in rats . Nat Prod Res. (2012)

Garcina Mangostana

Laad bronnen

Abu Bakar S, et al, DNA-seq analysis of Garcinia mangostana. Genom Data. (2015).

Lee HN, et al, Antitumor and apoptosis-inducing effects of α-mangostin extracted from the pericarp of the mangosteen fruit (Garcinia mangostana L.)in YD-15 tongue mucoepidermoid carcinoma cells. Int J Mol Med. (2016)

Abdallah HM, et al, Phenolics from Garcinia mangostana Inhibit Advanced Glycation Endproducts Formation: Effect on Amadori Products, Cross-Linked Structures and Protein Thiols. Molecules. (2016)

Franceschelli S, et al¸ A Novel Biological Role of α-Mangostin in Modulating Inflammatory Response through the Activation of SIRT-1 Signaling Pathway. J Cell Physiol. (2016)

Kritsanawong S, et al, Antiproliferative and apoptosis induction of α-mangostin in T47D breast cancer cells. Int J Oncol. (2016)

Polyorach S, et al, Rumen microorganisms, methane production, and microbial protein synthesis affected by mangosteen peel powder supplement in lactating dairy cows. Trop Anim Health Prod. (2016)

Onodera T, et al, Screening of mammalian DNA polymerase and topoisomerase inhibitors from Garcinia mangostana L. and analysis of human cancer cell proliferation and apoptosis. Int J Oncol. (2016)

Nguyen PT, et al, Anti-biofilm activity of α-mangostin isolated from Garcinia mangostana L. Z Naturforsch C.( 2015)

Chae HS, et al, Mangosteen Extract Attenuates the Metabolic Disorders of High-Fat-Fed Mice by Activating AMPK.J Med Food. (2016)

Janhom P, et al, Neuroprotective Effects of Alpha-Mangostin on MPP(+)-Induced Apoptotic Cell Death in Neuroblastoma SH-SY5Y Cells. J Toxicol. (2015)

Liu Y, et al, α- and γ-mangostin cause shape changes, inhibit aggregation and induce cytolysis of rat platelets.Chem Biol Interact. (2015)

Li W, et al, Isogarcinol Extracted from Garcinia mangostana L. Ameliorates Systemic Lupus Erythematosus-like Disease in a Murine Model. J Agric Food Chem. (2015)

Paengkoum P , et al, Molecular Weight, Protein Binding Affinity and Methane Mitigation of Condensed Tannins from Mangosteen-peel (Garcinia mangostana L). Asian-Australas J Anim Sci. (2015)

Xie Z, et al, Daily consumption of a mangosteen-based drink improves in vivo antioxidant and anti-inflammatory biomarkers in healthy adults: a randomized, double-blind, placebo-controlled clinical trial. Food Sci Nutr. (2015)

Ohno R, et al, Mangosteen pericarp extract inhibits the formation of pentosidine and ameliorates skin elasticity. J Clin Biochem Nutr. (2015)

Polyorach S, et al Effect of different levels of mangosteen peel powder supplement on the performance of dairy cows fed concentrate containing yeast fermented cassava chip protein. Trop Anim Health Prod. 2015

Wang A, et al Identification of hepatoprotective xanthones from the pericarps of Garcinia mangostana, guided with tert-butyl hydroperoxide induced oxidative injury in HL-7702 cells. Food Funct. (2015)

 

Bioperine

Laad bronnen

Shoba G, et al Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers . Planta Med. (1998)

Srinivasan K Black pepper and its pungent principle-piperine: a review of diverse physiological effects . Crit Rev Food Sci Nutr. (2007)


After Party Pack

Ingrediënten After Party Pack

 

Zink methionine

Magnesium Citraat

Alpha Liponzuur

Asparagyne zuur

Maria Distel

 

Zinc Methionine

Laad bronnen

Jensen JS, Wertz CF, O'Neill VA Preformulation stability of trans-resveratrol and trans-resveratrol glucoside (Piceid) . J Agric Food Chem. (2010)

Cai Y, et al Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer . Life Sci. (2004)

Han JH, et al Analgesic and anti-inflammatory effects of ethyl acetate fraction of Polygonum cuspidatum in experimental animals . Immunopharmacol Immunotoxicol. (2012)

Haase H, Rink L Functional significance of zinc-related signaling pathways in immune cells . Annu Rev Nutr. (2009)

Prasad AS Zinc in human health: effect of zinc on immune cells . Mol Med. (2008)

Prasad AS Clinical, immunological, anti-inflammatory and antioxidant roles of zinc . Exp Gerontol. (2008)

Prasad AS Zinc deficiency in human subjects . Prog Clin Biol Res. (1983)

Frederickson CJ, et al Importance of zinc in the central nervous system: the zinc-containing neuron . J Nutr. (2000)

Corona C1, et al Dietary zinc supplementation of 3xTg-AD mice increases BDNF levels and prevents cognitive deficits as well as mitochondrial dysfunction . Cell Death Dis. (2010)

Siwek M, et al Serum zinc level in depressed patients during zinc supplementation of imipramine treatment . J Affect Disord. (2010)

Tahmasebi Boroujeni S, et al The effect of severe zinc deficiency and zinc supplement on spatial learning and memory . Biol Trace Elem Res. (2009)

Kelishadi R, et al Effect of zinc supplementation on markers of insulin resistance, oxidative stress, and inflammation among prepubescent children with metabolic syndrome . Metab Syndr Relat Disord. (2010)

et al Possible mechanism by which zinc protects the testicular function of rats exposed to cigarette smoke . Pharmacol Rep. (2012)

 Rodondi A, et al Zinc increases the effects of essential amino acids-whey protein supplements in frail elderly . J Nutr Health Aging. (2009)

 Tupe RP, Chiplonkar SA Zinc supplementation improved cognitive performance and taste acuity in Indian adolescent girls . J Am Coll Nutr. (2009)

 Loguercio C, et al Trace elements and chronic liver diseases . J Trace Elem Med Biol. (1997)

 Somi MH, et al Effects of low dose zinc supplementation on biochemical markers in non-alcoholic cirrhosis: a randomized clinical trial . Arch Iran Med. (2012)

 Mansouri A, et al The effect of zinc sulfate in the prevention of high-dose chemotherapy-induced mucositis: a double-blind, randomized, placebo-controlled study .Hematol Oncol. (2012)

 Wilborn CD, et al Effects of Zinc Magnesium Aspartate (ZMA) Supplementation on Training Adaptations and Markers of Anabolism and Catabolism . J Int Soc Sports Nutr. (2004)

Magnesium

Laad bronnen

The effect of melatonin, magnesium, and zinc on primary insomnia in long-term care facility residents in Italy: a double-blind, placebo-controlled clinical trial

Fox C, Ramsoomair D, Carter C Magnesium: its proven and potential clinical significance . South Med J. (2001)

Langley WF, Mann D Central nervous system magnesium deficiency . Arch Intern Med. (1991)

Takase B, et al Effect of chronic stress and sleep deprivation on both flow-mediated dilation in the brachial artery and the intracellular magnesium level in humans .Clin Cardiol. (2004)

Spasov AA, et al Depression-like and anxiety-related behaviour of rats fed with magnesium-deficient diet . Zh Vyssh Nerv Deiat Im I P Pavlova. (2008)

Eby GA 3rd, Eby KL Magnesium for treatment-resistant depression: a review and hypothesis . Med Hypotheses. (2010)

Barragán-Rodríguez L, Rodríguez-Morán M, Guerrero-Romero F Efficacy and safety of oral magnesium supplementation in the treatment of depression in the elderly with type 2 diabetes: a randomized, equivalent trial . Magnes Res. (2008)

Rodríguez-Morán M, Guerrero-Romero F Oral magnesium supplementation improves insulin sensitivity and metabolic control in type 2 diabetic subjects: a randomized double-blind controlled trial . Diabetes Care. (2003)

The effect of melatonin, magnesium, and zinc on primary insomnia in long-term care facility residents in Italy: a double-blind, placebo-controlled clinical trial

Fox C, Ramsoomair D, Carter C Magnesium: its proven and potential clinical significance . South Med J. (2001)

Langley WF, Mann D Central nervous system magnesium deficiency . Arch Intern Med. (1991)

Takase B, et al Effect of chronic stress and sleep deprivation on both flow-mediated dilation in the brachial artery and the intracellular magnesium level in humans .Clin Cardiol. (2004)

Spasov AA, et al Depression-like and anxiety-related behaviour of rats fed with magnesium-deficient diet . Zh Vyssh Nerv Deiat Im I P Pavlova. (2008)

Eby GA 3rd, Eby KL Magnesium for treatment-resistant depression: a review and hypothesis . Med Hypotheses. (2010)

Barragán-Rodríguez L, Rodríguez-Morán M, Guerrero-Romero F Efficacy and safety of oral magnesium supplementation in the treatment of depression in the elderly with type 2 diabetes: a randomized, equivalent trial . Magnes Res. (2008)

Alpha Liponzuur

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α-lipoic acid can improve endothelial dysfunction in subjects with impaired fasting glucose

Wollin SD, Jones PJ Alpha-lipoic acid and cardiovascular disease . J Nutr. (2003)

Moini H, Packer L, Saris NE Antioxidant and prooxidant activities of alpha-lipoic acid and dihydrolipoic acid . Toxicol Appl Pharmacol. (2002)

Shay KP, et al Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential . Biochim Biophys Acta. (2009)

Jones W, et al Uptake, recycling, and antioxidant actions of alpha-lipoic acid in endothelial cells . Free Radic Biol Med. (2002)

Panigrahi M, et al alpha-Lipoic acid protects against reperfusion injury following cerebral ischemia in rats . Brain Res. (1996)

Schupke H, et al New metabolic pathways of alpha-lipoic acid . Drug Metab Dispos. (2001)

Suh JH, et al Dietary supplementation with (R)-alpha-lipoic acid reverses the age-related accumulation of iron and depletion of antioxidants in the rat cerebral cortex . Redox Rep. (2005)

McCarty MF, Barroso-Aranda J, Contreras F The "rejuvenatory" impact of lipoic acid on mitochondrial function in aging rats may reflect induction and activation of PPAR-gamma coactivator-1alpha . Med Hypotheses. (2009)

Hagen TM, et al (R)-alpha-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate .FASEB J. (1999)

Liu J, et al Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid . Proc Natl Acad Sci U S A. (2002)

Freisleben HJ, et al Influence of selegiline and lipoic acid on the life expectancy of immunosuppressed mice . Arzneimittelforschung. (1997)

Wang Y, et al alpha-Lipoic acid increases energy expenditure by enhancing adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor-gamma coactivator-1alpha signaling in the skeletal muscle of aged mice . Metabolism. (2010)

El Midaoui A, et al Impact of α-lipoic acid on liver peroxisome proliferator-activated receptor-α, vascular remodeling, and oxidative stress in insulin-resistant rats .Can J Physiol Pharmacol. (2011)

Seo EY, Ha AW, Kim WK α-Lipoic acid reduced weight gain and improved the lipid profile in rats fed with high fat diet . Nutr Res Pract. (2012)

Valdecantos MP, et al Lipoic acid administration prevents nonalcoholic steatosis linked to long-term high-fat feeding by modulating mitochondrial function . J Nutr Biochem. (2012)

Valdecantos MP, et al Lipoic Acid Improves Mitochondrial Function in Nonalcoholic Steatosis Through the Stimulation of Sirtuin 1 and Sirtuin 3 . Obesity (Silver Spring). (2012)

Kim E, et al A preliminary investigation of alpha-lipoic acid treatment of antipsychotic drug-induced weight gain in patients with schizophrenia . J Clin Psychopharmacol. (2008)

Zhang L, et al Alpha-lipoic acid protects rat cortical neurons against cell death induced by amyloid and hydrogen peroxide through the Akt signalling pathway .Neurosci Lett. (2001)

Farr SA, et al The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice . J Neurochem. (2003)

Stoll S, et al The potent free radical scavenger alpha-lipoic acid improves memory in aged mice: putative relationship to NMDA receptor deficits . Pharmacol Biochem Behav. (1993)

Han D, et al Protection against glutamate-induced cytotoxicity in C6 glial cells by thiol antioxidants . Am J Physiol. (1997)

Ferreira PM, Militão GC, Freitas RM Lipoic acid effects on lipid peroxidation level, superoxide dismutase activity and monoamines concentration in rat hippocampus . Neurosci Lett. (2009)

Bertolotto F, Massone A Combination of alpha lipoic acid and superoxide dismutase leads to physiological and symptomatic improvements in diabetic neuropathy .Drugs R D. (2012)

Chou TC, Shih CY, Chen YT Inhibitory effect of α-lipoic acid on platelet aggregation is mediated by PPARs . J Agric Food Chem. (2011)

Dinkova-Kostova AT, et al Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants . Proc Natl Acad Sci U S A. (2002)

Suh JH, et al Oxidative stress in the aging rat heart is reversed by dietary supplementation with (R)-(alpha)-lipoic acid . FASEB J. (2001)

Bae SC, et al Effects of antioxidant supplements intervention on the level of plasma inflammatory molecules and disease severity of rheumatoid arthritis patients .J Am Coll Nutr. (2009)

Ide T, et al Combined effect of sesamin and α-lipoic acid on hepatic fatty acid metabolism in rats . Eur J Nutr. (2012)

Vincent HK, et al Effects of alpha-lipoic acid supplementation in peripheral arterial disease: a pilot study . J Altern Complement Med. (2007)

Asparaginezuur

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Han D, et al Protection against glutamate-induced cytotoxicity in C6 glial cells by thiol antioxidants . Am J Physiol. (1997)

Ferreira PM, Militão GC, Freitas RM Lipoic acid effects on lipid peroxidation level, superoxide dismutase activity and monoamines concentration in rat hippocampus . Neurosci Lett. (2009)

Bertolotto F, Massone A Combination of alpha lipoic acid and superoxide dismutase leads to physiological and symptomatic improvements in diabetic neuropathy .Drugs R D. (2012)

Chou TC, Shih CY, Chen YT Inhibitory effect of α-lipoic acid on platelet aggregation is mediated by PPARs . J Agric Food Chem. (2011)

Dinkova-Kostova AT, et al Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants . Proc Natl Acad Sci U S A. (2002)

Suh JH, et al Oxidative stress in the aging rat heart is reversed by dietary supplementation with (R)-(alpha)-lipoic acid . FASEB J. (2001)

Bae SC, et al Effects of antioxidant supplements intervention on the level of plasma inflammatory molecules and disease severity of rheumatoid arthritis patients .J Am Coll Nutr. (2009)

Ide T, et al Combined effect of sesamin and α-lipoic acid on hepatic fatty acid metabolism in rats . Eur J Nutr. (2012)

Vincent HK, et al Effects of alpha-lipoic acid supplementation in peripheral arterial disease: a pilot study . J Altern Complement Med. (2007)

Gautam M, et al Immunomodulatory activity of Asparagus racemosus on systemic Th1/Th2 immunity: implications for immunoadjuvant potential . J Ethnopharmacol. (2009)

IN-VITRO ANTIOXIDANT ACTIVITY OF ASPARAGUS RACEMOSUS ROOTS

Singh GK, et al Antidepressant activity of Asparagus racemosus in rodent models . Pharmacol Biochem Behav. (2009)

Ramanathan M, Balaji B, Justin A Behavioural and neurochemical evaluation of Perment an herbal formulation in chronic unpredictable mild stress induced depressive model . Indian J Exp Biol. (2011)

Sharma P, et al A unique immuno-stimulant steroidal sapogenin acid from the roots of Asparagus racemosus . Steroids. (2011)

Thakur M, et al Improvement of penile erection, sperm count and seminal fructose levels in vivo and nitric oxide release in vitro by ayurvedic herbs . Andrologia. (2011)

Bhatnagar M, Sisodia SS, Bhatnagar R Antiulcer and antioxidant activity of Asparagus racemosus Willd and Withania somnifera Dunal in rats . Ann N Y Acad Sci. (2005)

Palanisamy N, Manian S Protective effects of Asparagus racemosus on oxidative damage in isoniazid-induced hepatotoxic rats: an in vivo study . Toxicol Ind Health. (2012)

Maria Distel

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Abenavoli L, et al Milk thistle in liver diseases: past, present, future . Phytother Res. (2010)

Abenavoli L, et al Complementary therapies for treating alcoholism First Annual meeting by Complementary Medicine Research Group of the Italian Society for Alcohol Studies-May 5, 2006, Florence, Italy . Fitoterapia. (2008)

Pradhan SC, Girish C Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine . Indian J Med Res. (2006)

Kidd PM Bioavailability and activity of phytosome complexes from botanical polyphenols: the silymarin, curcumin, green tea, and grape seed extracts . Altern Med Rev. (2009)

Tyagi AK, et al Silibinin strongly synergizes human prostate carcinoma DU145 cells to doxorubicin-induced growth Inhibition, G2-M arrest, and apoptosis . Clin Cancer Res. (2002)

Song Z, et al Silymarin prevents palmitate-induced lipotoxicity in HepG2 cells: involvement of maintenance of Akt kinase activation . Basic Clin Pharmacol Toxicol. (2007)

Saller R, et al An updated systematic review with meta-analysis for the clinical evidence of silymarin . Forsch Komplementmed. (2008)

Jayaraj R, et al Hepatoprotective efficacy of certain flavonoids against microcystin induced toxicity in mice . Environ Toxicol. (2007)